IBL/骨保护素ELISA/BV51101/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 2x1h;1x30min;1x10min |
| Standardrange | 1.5-60pmol/L |
| Specimen/Volumes | 100µLserum,plasma,synovialfluid,cellculturemedium |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | EU:CE |
Detailsfor:OsteoprotegerinELISA
Osteoprotegerin(OPG)orosteoclastogenesisinhibitoryfactor(OCIF),aproductoftheTNFRSF11Bgenelocatedinchromosome8q24,isamemberoftheTNFreceptorsuperfamilythatplaysakeyroleinboneremodeling.
HumanOPGisa401aminoacidsecretedglycoproteinthatexistsnaturallyaseithera120kDAdisulfide-linkedhomodimeror60kDamonomer.OPGisactiveaseitheramonomerordimer,withthedimershowingmorepotentbioactivity.UnlikemostmembersoftheTNFreceptorsuperfamily,OPGaparentlyexistsonlyinasolubleformasadecoyreceptorforitsligands,RANKL(TNFSF11,OPGL,ODF,TRANCE)andTRAIL.
Human
OPGshares85%and86%aminoacididentitytomouseandratOPGrespectively.Inhumanadults,OPGmRNAishighlyexpresedinvarioustissues,e.g.bone,skin,liver,stomach,intestine,heart,brainandlung.
OsteoprotegerininhibitsthebindingofRANKLtoRANK(osteoclastdifferentiationandactivationreceptor,ODAR)ontheosteoclastsurfaceandthus,OPGisanaturalantagoNISTtoRANKL-inducedosteoclastogenesisandboneresorption.SinceOPGexhibitsaninhibitoryeffectonosteoclasts,itactsasasolublefactorintheregulationofbonemass.
OsteoclastformationactivitymaybemonitoredprincipallybydeterminationoftheconcentrationratioofRANKL/OPG.Alterationofthisratiomaybethecauseofbonelossinmanyimbalancesinbonemetabolismsuchasosteoporosis,osteopetrosis,hypercalcemia,metastaticosteolyticlesionsandrheumaticbonedegradation.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.HumanOPGisa401aminoacidsecretedglycoproteinthatexistsnaturallyaseithera120kDAdisulfide-linkedhomodimeror60kDamonomer.OPGisactiveaseitheramonomerordimer,withthedimershowingmorepotentbioactivity.UnlikemostmembersoftheTNFreceptorsuperfamily,OPGaparentlyexistsonlyinasolubleformasadecoyreceptorforitsligands,RANKL(TNFSF11,OPGL,ODF,TRANCE)andTRAIL.
Human
OPGshares85%and86%aminoacididentitytomouseandratOPGrespectively.Inhumanadults,OPGmRNAishighlyexpresedinvarioustissues,e.g.bone,skin,liver,stomach,intestine,heart,brainandlung.
OsteoprotegerininhibitsthebindingofRANKLtoRANK(osteoclastdifferentiationandactivationreceptor,ODAR)ontheosteoclastsurfaceandthus,OPGisanaturalantagoNISTtoRANKL-inducedosteoclastogenesisandboneresorption.SinceOPGexhibitsaninhibitoryeffectonosteoclasts,itactsasasolublefactorintheregulationofbonemass.
OsteoclastformationactivitymaybemonitoredprincipallybydeterminationoftheconcentrationratioofRANKL/OPG.Alterationofthisratiomaybethecauseofbonelossinmanyimbalancesinbonemetabolismsuchasosteoporosis,osteopetrosis,hypercalcemia,metastaticosteolyticlesionsandrheumaticbonedegradation.
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