IBL/Interleukin-6 / IL-6 (rat) ELISA/BE45361/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h,1x1h,1x10min |
| Standardrange | 31.3-2000pg/mL |
| Specimen/Volumes | 50µlserum,cellculturesupernatant |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Interleukin-6/IL-6(rat)ELISA
Interleukin-6(IL-6)isamulti-functionalcytokinethatregulatesimmuneresponses,acutephasereactionsandhematopoiesisandmayplayacentralroleinhostdefensemechanisms.
IL-6isusuallynotproducedconstitutivelybynormalcells,butitsexpressionisreADIlyinducedbyavarietyofcytokines,lipopolysaccharideorviralinfections.IL-6isapleiotropiccytokineproducedbyavarietyofcells.Itactsonawiderangeoftissues,exertinggrowth-induction,growth-inhibition,anddifferentiationrespectively,dependingonthenatureofthetargetcells.
IL-6isinvolvedin
-theinductionofB-celldifferentiation
-theinductionofacutephaseproteinsinlivercells
-growthpromotionofmyeloma/plasmacytoma/hybridomacells
-inductionofIL-2andIL-2receptorexpression
-proliferationanddifferentiationofTcells
-inhibitionofcellgrowthofcertainmyeloidleukemiccelllinesandinductionoftheirdifferentiationtomacrophages
-enhancementofIL-3-inducedmultipotentialcolonycellformationinhematopoieticstemcellsandinductionofmaturationofmegakaryocytesasathrombopoieticfactor
-inductionofmesangialcellgrowth
-inductionofneuraldifferentiationofPC12cellsand
-inductionofkeratinocytegrowth
TheabnormalproductionofIL-6wasfirstsuggestedtoberelatedtopolyclonalB-cellactivationwithautoantibodyproductioninpatientswithcardiacmyxoma.Sincethen,IL-6hasbeensuggestedtobeinvolvedinthepathogenesisofavarietyofdiseases.MeasurementofIL-6levelsinserumandotherbodyfluidsthusprovidesmoredetailedinsightsintovariouspathologicalsituations.
Synonyms:Interferon-beta2,B-cellstimulatoryfactor2,HGF
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.IL-6isusuallynotproducedconstitutivelybynormalcells,butitsexpressionisreADIlyinducedbyavarietyofcytokines,lipopolysaccharideorviralinfections.IL-6isapleiotropiccytokineproducedbyavarietyofcells.Itactsonawiderangeoftissues,exertinggrowth-induction,growth-inhibition,anddifferentiationrespectively,dependingonthenatureofthetargetcells.
IL-6isinvolvedin
-theinductionofB-celldifferentiation
-theinductionofacutephaseproteinsinlivercells
-growthpromotionofmyeloma/plasmacytoma/hybridomacells
-inductionofIL-2andIL-2receptorexpression
-proliferationanddifferentiationofTcells
-inhibitionofcellgrowthofcertainmyeloidleukemiccelllinesandinductionoftheirdifferentiationtomacrophages
-enhancementofIL-3-inducedmultipotentialcolonycellformationinhematopoieticstemcellsandinductionofmaturationofmegakaryocytesasathrombopoieticfactor
-inductionofmesangialcellgrowth
-inductionofneuraldifferentiationofPC12cellsand
-inductionofkeratinocytegrowth
TheabnormalproductionofIL-6wasfirstsuggestedtoberelatedtopolyclonalB-cellactivationwithautoantibodyproductioninpatientswithcardiacmyxoma.Sincethen,IL-6hasbeensuggestedtobeinvolvedinthepathogenesisofavarietyofdiseases.MeasurementofIL-6levelsinserumandotherbodyfluidsthusprovidesmoredetailedinsightsintovariouspathologicalsituations.
Synonyms:Interferon-beta2,B-cellstimulatoryfactor2,HGF
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