IBL/γ干扰素（大鼠）ELISA/BE45301/
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产品分类：
夹心法ELISA
公司分类：
Sandwich_method_ELISA
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Kitsize | 12x8 |
| Method | ELISA |
| Incubationtime | 1x2h,1x1h,1x10min |
| Standardrange | 15.6-1000pg/mL |
| Specimen/Volumes | 50µLserum,plasma,cellculturesupernatantetal. |
| Substrate/isotope | TMB450nm |
| RegulatoryStatus: | Forresearchuseonly |
Detailsfor:Interferon-gamma(rat)ELISA
IFN-gamma,alsocalledTypeIIIinterferon,isahomodimericglycoproteincontainingapproximately21to24kDsubunits.IncontrasttoIFN-alphaandIFN-betasynthesis,whichcanoccurinanycell,productionofIFN-gammaisafunctionofTcellsandNKcells.AllIFN-gammainducersactivateTcellseitherinapolyclonal(mitogensorantibodies)orinaclonallyrestricted,antigen-specific,manner.IFN-gammaisproducedduringinfectionbyTcellsofthecytotoxic/suppressorphenotype(CD8)andbyasubtypeofhelperTcells,theTh1cells.Th1cellssecreteIL-2,IL-3,TNF-betaandIFN-gamma,whereasTh4cellsmainlyproduceIL-3,IL-4,IL-5,andIL-10,butlittleornoIFN-gamma.IFN-gammapreferentiallyinhibitstheproliferationofTh4butnotTh1cells,indicatingthatthepresenceofIFN-gammaduringanimmuneresponsewillresultinthepreferentialproliferationofTh1cells.
TypeIIIFNorIFN-gammaisalymphokinethatdisplaysnomolecularhomologywithtypeIIFN,butsharessomeimportantBIOLOGicactivities.Specifically,IFN-gammainducesananti-viralstateandisantiproliferative.Inaddition,IFN-gammahasseveralpropertiesrelatedtoimmunoregulation.
(1)IFN-gammaisapotentactivatorofmononuclearphagocytes,augmentsendocytosisandphagocytosisbymonocytes,andactivatesmacrophagestokilltumorcellsbyreleasingreactiveoxygenintermediatesandTNF-alpha.
(2)IFN-gammainducesoraugmentstheexpressionofMHCantigensonmacrophages,TandBcellsandsometumorcelllines.
(3)OnTandBcellsIFN-gammapromotesdifferentiation.
(4)Finally,IFN-gammaactivatesneutrophils,NKcellsandvascularendothelialcells.
Synonyms:Immuneinterferon,IFG
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.TypeIIIFNorIFN-gammaisalymphokinethatdisplaysnomolecularhomologywithtypeIIFN,butsharessomeimportantBIOLOGicactivities.Specifically,IFN-gammainducesananti-viralstateandisantiproliferative.Inaddition,IFN-gammahasseveralpropertiesrelatedtoimmunoregulation.
(1)IFN-gammaisapotentactivatorofmononuclearphagocytes,augmentsendocytosisandphagocytosisbymonocytes,andactivatesmacrophagestokilltumorcellsbyreleasingreactiveoxygenintermediatesandTNF-alpha.
(2)IFN-gammainducesoraugmentstheexpressionofMHCantigensonmacrophages,TandBcellsandsometumorcelllines.
(3)OnTandBcellsIFN-gammapromotesdifferentiation.
(4)Finally,IFN-gammaactivatesneutrophils,NKcellsandvascularendothelialcells.
Synonyms:Immuneinterferon,IFG
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