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当前位置: 首页 > 产品中心 > Sandwich_method_ELISA > IBL/IGFBP-3 ELISA/MG59131/
商品详细IBL/IGFBP-3 ELISA/MG59131/
IBL/IGFBP-3 ELISA/MG59131/
IBL/IGFBP-3 ELISA/MG59131/
商品编号: MG59131
品牌: TECAN
市场价: ¥0.00
美元价: 0.00
产地: 美国(厂家直采)
公司:
产品分类: 夹心法ELISA
公司分类: Sandwich_method_ELISA
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Kitsize12x8
MethodELISA
Incubationtime1x2h,1x30min
Standardrange460-46070ng/mL
Specimen/Volumes10µLserum
Substrate/isotopePNPP405nm
RegulatoryStatus:EU:CE
Detailsfor: IGFBP-3ELISA
Theinsulin-likegrowthfactor(IGF)systemistheprimaryregulatorofnormalbodygrowthandregeneration,affectingcellproliferation,differentiationandapoptosis.Inaddition,theIGF-systemappearstomodifyinsulinsensitivityandlong-termglucosemetabolism.Finally,numerousepidemiological,experimentalandclinicaldataindicatethattheIGF-systemisalsoinvolvedinthedevelopmentofseveralcommoncancersaswellasfrequentdiseasessuchasatherosclerosisandtype2diabetesmellitus.TheIGF-systemconsistsofafamilyofcloselyrelatedpeptides,whichincludesthetwoprimarygrowthpromotingpeptides,IGF-IandIGF-II,6specifichigh-affinityIGF-bindingproteins(IGFBP-1to-6),andalargenon-IGF-bindingglycoprotein,the“acidlABIlesubunit”(ALS).IGFBP-3isthemostabundantIGF-bindingprotein,accountingforasmuchas75%ormoreofthecirculatingIGF-bindingcapacityinhealthysubjects.IGFBP-3sharesfunctionalpropertieswithIGFBP-5inthatbothpeptidesareabletoformhighmolecularweightternarycomplexesof~150kiloDaltonwithALSandeitherIGF-Ior–II.However,IGFBP-5circulatesinmuchlowerconcentrationsthanIGFBP-3,andinhealthysubjectstheternarycomplexescarryasmuchas90%ofIGFBP-3butonlyabout50%ofIGFBP-5.Originally,theIGFBPswerethoughttoserveasIGF-carrierproteins,stabilizingplasmaIGFlevelsandcontrollingtheegressofIGFfromthecirculationtotheextra-vascularcompartment.FurThermore,itwasassumedthatIGFBP-complexedIGFwasBIOLOGicallymoreorlessinactive,beingdepriveditsabilitytointeractwiththeIGF-Ireceptor.However,itsoonbecameapparentthatinsomeexperimentalsettingstheIGFBPsstimulatedratherthaninhibitedIGF-Imediatedactions,andaccordingly,theIGFBPsarenowoftenreferredtoasmodulatorsofIGF-Ibioactivity.Inaddition,themajorityoftheIGFBPs,andinparticularIGFBP-3,exertsIGF-IandIGF-Ireceptorindependenteffects,possIBLeinvolvinginteractionswithspecificreceptorslocatedatthecellsurfaceandintracellular.Forexample,IGFBP-3isnowadaysconsideredtoserveasananti-cancermolecule,apparentlyprotectingagainstseveralcommoncancers,andeffectsofIGFBP-3oninsulinsignalinginculturedADIpocyteshavealsobeensuggested.Theturnoveroftheternarycomplexesisveryslow,andtheplasmaconcentrationofIGFBP-3remainsstablethroughouttheday,beingunaffectedbyshort-termnutritionalchanges.Thus,thelevelofIGFBP-3maybedeterminedbyonesinglemeasurement.GHistheprimaryregulatorofIGFBP-3aswellasofIGF-IandALSandtherefore,allthreepeptidesincreaseduringthepubertalgrowthspurt,whereafterlevelsgraduallydeclinewithincreasingage.Inchildren,IGFBP-3hasbeenshowntocorrelatewiththe24-hintegratedGHsecretionandinparticularinchildrenIGFBP-3maybehelpfulinthediagnosisofGHdeficiency.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
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